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Author Topic: Growth plates: nobody is even trying  (Read 1924 times)

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Alcibiades

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Growth plates: nobody is even trying
« on: July 16, 2024, 12:48:01 AM »

After reading every study and statement by scientists I could get my hands on, even paying for papers, I’ve reached these two conclusions.

1. It seems surprisingly uncontroversial to say that we could probably introduce new growth plates into the long bones of animals. This would most likely involve seeding a collagen matrix with stem cells from growth plate cartilage, scraping off the diaphyseal shafts of a long bone, getting the matrix to adhere to the long bone, and stimulating it with growth hormone.

As someone with some science background, in principle this really doesn't sound all that far-fetched to do. The basic principles here have worked for other tissues. It seems like a lab with the resources could start animal studies tomorrow.

2. Despite vague statements in the CLL world, nobody is doing this research. The only ongoing research seems to focus on using stem cells to repair damaged growth plates in juvenile animals. Hadley-Miller is looking into stopping existing growth plates from becoming bone, for example.

Evidently researchers / investors just don't see the financial incentive to even try here. That’s surprising given the multibillion-dollar size of the CLL industry and its projected growth [https://www.sphericalinsights.com/reports/limb-leg-lengthening-surgery-market].

Possible solutions I'd be interested in discussing with any serious inquirer:

A. Creating a DAO that would pool money to invest, on behalf of the DAO owners, in any growth plate creation venture; or:

B. Probably less viable: creating a DAO that would raise funds to donate to research in growth plate creation.

Alternatively, if anyone knows of any old forum or community where I should post this, let me know. I wouldn’t expect any of the Reddits to be any help.
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iwillgettaller

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Re: Growth plates: nobody is even trying
« Reply #1 on: July 16, 2024, 05:38:16 AM »

maybe you can check out naturalheightgrowth.com and heightquest on instagram.  They seem to have some information on trying to grow without surgery after your growth plates closes.
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HateLAPELoveSTEM

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Re: Growth plates: nobody is even trying
« Reply #2 on: July 16, 2024, 05:42:52 AM »

maybe you can check out naturalheightgrowth.com and heightquest on instagram.  They seem to have some information on trying to grow without surgery after your growth plates closes.
I tried LSJL and it did not work even in the slightest bit, and neither did his recommended Glu-thinggy.
The web compiled up some pseudoscientific bs and be distinguishable enough when you browse the web.
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Alcibiades

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Re: Growth plates: nobody is even trying
« Reply #3 on: July 16, 2024, 02:46:05 PM »

maybe you can check out naturalheightgrowth.com and heightquest on instagram.  They seem to have some information on trying to grow without surgery after your growth plates closes.

Disappointing. Why would people be breaking their bones if there was a non-surgical method? This is a way for this guy to sell PDFs. The favorable comments on his YouTube channel are visibly from bots.

Exercises and other lifestyle choices might help somewhat for people under 25, since there may be some growth plates until the mid-20s. That's the only kernel of truth to any therapy like this.
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AllinStryde

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Re: Growth plates: nobody is even trying
« Reply #4 on: July 16, 2024, 07:51:26 PM »

There is a way to reopen growth-plates...with an Osteotome.  Iykyk.
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onedaytall

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Re: Growth plates: nobody is even trying
« Reply #5 on: July 17, 2024, 12:19:41 AM »

"nobody is doing this research"

I mean, from their point of view, maybe a bunch of manlets wanting to grow taller just isn't worth the funding and long haul scientific work to chase height growth for adults? I imagine they would have more pressing issues to work on and more lucrative projects to capitalise on. Maybe when the research and similar fields are already more advanced, then it is easier for someone to grab this avenue and make something of it.

Just imagine trying to sell a pipe dream of making adults grow taller to get funding for your scientific research that is almost at square one.
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Alcibiades

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Re: Growth plates: nobody is even trying
« Reply #6 on: July 17, 2024, 02:44:38 AM »

CLL and LLD are already multibillion dollar industries. If you could create growth plates, even just for long bones, it would probably be the second most popular cosmetic procedure for men on the planet after hair transplants.

The basics of using stem cells to grow new tissues are already pretty well-understood, so we're not at square one. There just isn't any ongoing attempt to use them to create growth plates.

In order to get from step 0 to step 1, someone would first have to be committed to trying it, at least until you have ASI growing things for us from stem cells.

A little surprised I haven't spotted any sciences or venture people around here. Makes me wonder what fields most people are in.
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